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, Meizhi He State Key Laboratory of Organ Failure Research, Division of Nephrology, Nanfang Hospital, Southern Medical University National Clinical Research Center of Kidney Disease, Guangdong Provincial Institute of Nephrology , Guangzhou , China Search for other works by this author on: Oxford Academic Zhao Liu State Key Laboratory of Organ Failure Research, Division of Nephrology, Nanfang Hospital, Southern Medical University National Clinical Research Center of Kidney Disease, Guangdong Provincial Institute of Nephrology , Guangzhou , China Search for other works by this author on: Oxford Academic Li Li State Key Laboratory of Organ Failure Research, Division of Nephrology, Nanfang Hospital, Southern Medical University National Clinical Research Center of Kidney Disease, Guangdong Provincial Institute of Nephrology , Guangzhou , China Search for other works by this author on: Oxford Academic Youhua Liu State Key Laboratory of Organ Failure Research, Division of Nephrology, Nanfang Hospital, Southern Medical University National Clinical Research Center of Kidney Disease, Guangdong Provincial Institute of Nephrology , Guangzhou , China Correspondence to: Youhua Liu; E-mail: liuyh@smu.edu.cn Search for other works by this author on: Oxford Academic
https://orcid.org/0000-0001-7582-0511 Nephrology Dialysis Transplantation, Volume 39, Issue 5, May 2024, Pages 761–769, https://doi.org/10.1093/ndt/gfad257
Published:
01 December 2023
Article history
Received:
27 September 2023
Published:
01 December 2023
Corrected and typeset:
14 December 2023
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Meizhi He, Zhao Liu, Li Li, Youhua Liu, Cell–cell communication in kidney fibrosis, Nephrology Dialysis Transplantation, Volume 39, Issue 5, May 2024, Pages 761–769, https://doi.org/10.1093/ndt/gfad257
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ABSTRACT
Kidney fibrosis is a common outcome of a wide variety of chronic kidney diseases, in which virtually all kinds of renal resident and infiltrating cells are involved. As such, well-orchestrated intercellular communication is of vital importance in coordinating complex actions during renal fibrogenesis. Cell–cell communication in multicellular organisms is traditionally assumed to be mediated by direct cell contact or soluble factors, including growth factors, cytokines and chemokines, through autocrine, paracrine, endocrine and juxtacrine signaling mechanisms. Growing evidence also demonstrates that extracellular vesicles, lipid bilayer–encircled particles naturally released from almost all types of cells, can act as a vehicle to transfer a diverse array of biomolecules including proteins, mRNA, miRNA and lipids to mediate cell–cell communication. We recently described a new mode of intercellular communication via building a special extracellular niche by insoluble matricellular proteins. Kidney cells, upon injury, produce and secrete different matricellular proteins, which incorporate into the local extracellular matrix network, and regulate the behavior, trajectory and fate of neighboring cells in a spatially confined fashion. This extracellular niche–mediated cell–cell communication is unique in that it restrains the crosstalk between cells within a particular locality. Detailed delineation of this unique manner of intercellular communication will help to elucidate the mechanism of kidney fibrosis and could offer novel insights in developing therapeutic intervention.
cell–cell communication, EVs, fibrogenic niche, kidney fibrosis, matricellular protein
© The Author(s) 2023. Published by Oxford University Press on behalf of the ERA.
This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)
Topic:
- fibrosis
- cell communication
- growth factor
- kidney
- intercellular communication
Issue Section:
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